Molecular analysis of colon biopsy or colon tumor for prognosis and targeted therapy

Relative gene expression

EGFR

HER2

ERBB3

IGF1R

C-KIT

MET

VEGFR2

PDGFRa

CXCR4

P53

CYCLIN D1

PTEN

COX2

BCL2

SURVIVIN

FAP

MACC1

Relative quantitative gene expression for prediction of response to chemotherapy

 BCRP (platinum,irinotecan,topotecan)
 MRP1 (cyclophoshamide,etoposide,vincristine)
 ERCC1,BRCA1 (platinum)
 TYMS (5-FU,capecitabine,pemetrexed)
 PGP(doxorubicin,paclitaxel,etoposide,vincristine)
 RRΜ1,RRΜ2,HUR (gemcitabine)
 TUBB3,SPARC,TLE3,TAU (taxanes)
 MGMT (temozolomide)

HIGH EXPRESSION -> NO RESPONSE

TOPO2A

 (doxorubicin,epirubicin)

TOPO1

(irinotecan,etoposide)

HIGH EXPRESSION -> RESPONSE

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