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Breast-Ovarian Cancer PDF Print E-mail
Friday, 26 November 2010 21:09

Detection of genetic predisposition for breast and ovarian cancer by DNA sequencing of BRCA1 and BRCA2 genes. 

BRCA1 gene

Individuals with BRCA1 mutations are at increased risk for breast and ovarian cancers. It is reported that women who carry alterations in the BRCA1 gene have up to an 85% lifetime risk of developing breast cancer and a 40-60% lifetime risk of developing ovarian cancer. This is compared to the 10-12% lifetime risk of breast cancer and 1-2% lifetime risk of ovarian cancer observed in the general population.

BRCA2 gene

Mutations in BRCA2 account for up to 15% of families with hereditary breast cancer. Women who carry alterations in BRCA2 have up to an 85% lifetime risk of developing breast cancer and up to 27% risk of developing ovarian cancer.

 

 

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