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Molecular analysis of head and neck biopsy

for prognosis and targeted therapy

 

 

  • Relative gene expression

EGFR

 ERBB2
ERBB3

MET

VEGFR2

PDGFRα

C-KIT

FOXM1

IGFIR

CXCR4

CD133

CYCLIN D1
PTEN

OSTEOPONTIN

SURVIVIN

P13Kα

ΑΚΤ

mTOR

DNMT1

 

  • Relative quantitative gene expression for response to chemotherapy

BCRP (platinum,irinotecan,topotecan)
MRP1 (cyclophoshamide,etoposide,vincristine)
ERCC1,BRCA1 (platinum)
TYMS (5-FU,capecitabine,pemetrexed)
PGP (doxorubicin,paclitaxel,etoposide,vincristine)
RRΜ1, RRΜ2,HUR (gemcitabine)
TUBB3,SPARC,TLE3,TAU (taxanes)
MGMT (temozolomide)

HIGH EXPRESSION

↓

NO RESPONSE

TOPO2A

(doxorubicin,epirubicin)

TOPO1

(irinotecan,etoposide)

HIGH EXPRESSION

↓

RESPONSE
 

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