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Cervical Cancer PDF Print E-mail

Molecular analysis of Cervical biopsy sample

for prognosis and targeted therapy

  • Relative gene expression

EGFR

ERBB2

ERBB3

ESR1α

MET

VEGFR2

PDGFRα

IGF1R

CXCR4

CD133

CYCLIN D1

PTEN

COX2

SURVIVIN

TERT

MMP2

DNMT1

 

  • Relative Quantitative Gene Expression for response to chemotherapy

BCRP (platinum,irinotecan,topotecan)
MRP1 (cyclophoshamide,etoposide,vincristine)
ERCC1,BRCA1 (platinum)
TYMS (5-FU,capecitabine,pemetrexed)
PGP (doxorubicin,paclitaxel,etoposide,vincristine)
RΡΜ1,RΡΜ2,HUR (gemcitabine)
TUBB3,SPARC,TLE3,TAU (taxanes)
MGMT (temozolomide)

HIGH EXPRESSION

NO RESPONSE

 

TOPO2A

(doxorubicin,epirubicin)

TOPO1

(irinotecan,etoposide)

HIGH EXPRESSION

RESPONSE

 

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targeted_therapy-kinase_inhibitor.jpg


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