Molecular analysis of pancreatic biopsy for prognosis
and targeted therapy

-
Relative quantitative gene expression for prediction of response
to chemotherapy
BCRP (platinum,irinotecan,topotecan)
|
MRP1 (cyclophoshamide,etoposide,vincristine)
|
ERCC1,BRCA1 (platinum)
|
TYMS (5-FU,capecitabine,pemetrexed)
|
PGP (doxorubicin,paclitaxel,etoposide,vincristine)
|
RRΜ1,RRΜ2,HUR (gemcitabine)
|
TUBB3,SPARC,TLE3,TAU(taxanes)
|
MGMT (temozolomide)
|
HIGH EXPRESSION
↓
NO RESPONSE
TOPO2A
(doxorubicin,epirubicin)
|
TOPO1
(irinotecan,etoposide)
|
HIGH EXPRESSION
↓
RESPONSE
|