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Pancreatic Cancer PDF Print E-mail

Molecular analysis of pancreatic biopsy for prognosis

and targeted therapy

  • Relative gene expression

EGFR

ERBB2

ERBB3

IGF1R

PTEN

MET

VEGFR2

PDGFRα

CXCR4

CD133

CYCLIN D1

DNMT1

SURVIVIN

EGFR(L858R)

EGFR(Δ746-750)

 

 

 

 

 

  • Relative quantitative gene expression for prediction of response

to chemotherapy

BCRP (platinum,irinotecan,topotecan)

MRP1 (cyclophoshamide,etoposide,vincristine)

ERCC1,BRCA1 (platinum)

TYMS (5-FU,capecitabine,pemetrexed)

PGP (doxorubicin,paclitaxel,etoposide,vincristine)

RRΜ1,RRΜ2,HUR (gemcitabine)

TUBB3,SPARC,TLE3,TAU(taxanes)

MGMT (temozolomide)

HIGH EXPRESSION

↓

NO RESPONSE

 

 

TOPO2A

(doxorubicin,epirubicin)

TOPO1

(irinotecan,etoposide)

HIGH EXPRESSION

↓

RESPONSE
 

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