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Lung Ca PDF Print E-mail

Molecular analysis of lung tumor sample or lung FNA sample

for prognosis and targeted therapy

 

  • Relative gene expression  

EGFR

  HER2

ERBB3

IGF1R

C-KIT

MET

VEGFR2

PDGFRα

CXCR4

P53

 CYCLIN D1

 PTEN

 COX2

 EGFR(L858R)

 EGFR(Δ746-750)

 EGFRvIII

 EML4-ALK

  

 

 

 

 

 

 

 

 

  • Relative quantitative gene expression for prediction of response

       to chemotherapy

 BCRP (platinum,irinotecan,topotecan)

 MRP1 (cyclophoshamide,etoposide,vincristine)

 ERCC1,BRCA1 (platinum)

 TYMS (5-FU,capecitabine,pemetrexed)

 PGP(doxorubicin,paclitaxel,etoposide,vincristine)

 RRΜ1,RRΜ2,HUR (gemcitabine)

 TUBB3,SPARC,TLE3,TAU (taxanes)

 MGMT (temozolomide)

 

HIGH EXPRESSION

↓

NO RESPONSE

 

 

TOPO2A

(doxorubicin,epirubicin)

TOPO1  

(irinotecan,etoposide)

 

HIGH EXPRESSION

↓

RESPONSE
 

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